Drug labelling

Immuno-gold Labelling of Chlamydia trachomatis

Background Chlamydia trachomatis is considered as an important cause of preventable sexually transmitted diseases worldwide. It is known to be of an obligate intracellular nature and enters its target cells via an endocytic process. As major outer membrane protein (MOMP) is one of the main candidates for the attachment and entry of chlamydia to the host cells we have tried to label the epitopes...

On Labelling Statements in Multi-Labelling Argumentation

In computational models of argumentation, argument justification has attracted more attention than statement justification, and significant sensitivity losses are identifiable when dealing with the justification of statements by otherwise appealing formalisms. This paper reappraises statement justification as a formalism-independent component in argument-based reasoning. We introduce a novel ge...

Sulfonium Salts as Leaving Groups for Aromatic Labelling of Drug-like Small Molecules with Fluorine-18

Positron emission tomography (PET) is unique in that it allows quantification of biochemical processes in vivo, but difficulties with preparing suitably labelled radiotracers limit its scientific and diagnostic applications. Aromatic [(18)F]fluorination of drug-like small molecules is particularly challenging as their functional group compositions often impair the labelling efficiency. Herein, ...

Reduction of deaths after drug labelling for risk of Reye's syndrome.

Drug responses of adenylate cyclase in iris-ciliary body determined by adenine labelling.

The intracellular adenine nucleotide pool of rabbit iris-ciliary body was labelled by uptake of 3H-adenine in vitro. A variety of agents were tested for their ability to stimulate or inhibit the incorporation of radioactivity into cyclic AMP formed from ATP labelled with 3H-adenine. Isoproterenol, vasoactive intestinal peptide, forskolin, and prostaglandin E2 stimulated incorporation of label 3...